STH MULTIDISCIPLINARY INTERNATIONAL

Conference of Biological Psychiatry

«Stress and Behavior»

Proceedings of the 9th International Multidisciplinary Conference «Stress and behavior» Saint-Petersburg, Russia, 16-19 May 2005 Editor: Allan V. Kalueff, PhD

CONFERENCE ABSTRACTS

6. GENERAL QUESTIONS:

PSYCHIATRY OF STRESS

REGULATION OF STRESS-SEQUENTIAL MICRONUTRITION

M. Lugand Bourgeois, A. Cornely Bioresearch and Partners, Monthey, Switzerland

Stress is a real public health issue because of its multiples consequences. Bioresearch and Partners’ objective is to exploit a new nutritional approach: micronutrition which can be used in acute as well as in chronic stress. The micronutritional approach developed by Bioresearch & Partners is a new mode of utilizing nutrients which targets an action on the global regulation of stress; the nutrients have been selected to participate in a nutritional strategy aiming to help the organism in the regulation of stress homeostasis. Design: This randomised, double-blind, placebo-controlled study verified the efficacy of micronutrition on 8-week treatment period in patients with generalized stress disorder.

Subjects: The study group consisted of 158 subjects two groups (81 micronutrition — 77 placebos) average age: 42.5 (69 men, 89 women). Measurements: Subjects’ symptoms were collected before treatment and after 8 weeks of treatment. Inclusion requires 18 minimum points (3 central and 3 somatic symptoms) in Hamilton Rating Scale for stress (HAM-S). Total score was measured and compared in the two groups.

Results: After 8 weeks of follow-up, the total score decreased of 42.9% in the micronutrition group versus 19.7% in the placebo group. Total score: 2168 to 1238 for micronutrition group, 1973 to 1585 for placebo group.65% of micronutrition group get out of the inclusion criteria (score under 18) versus 35% versus placebo.

Conclusion: Decreased of total score (HAM-S) corresponding in disappearance of intensity stress symptoms (42.9% vs. 19.7%) offer a satisfactory response to the required therapeutic aims in a population presenting a generalized stress disorder. Micronutrisequence is efficient in stress, and offer a new response in situations which do not always require drugs in cases other than pathologic situation requiring anxiolytic drug.

Psychopharmacol. Biol. Narcol. 2005. Vol. 5, N 2. P. 922—923

Psyhopharmacology & biological narcology

ISSN Шб-БШ